INDIAN STATISTICAL SERVICE(ISS) SYLLABUS
SUNRISE CLASSES IS IN LAXMI NAGAR NEAR METRO STATION EXIT FROM GATE NO. 5

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RBI Grade B (DR)-DSIM 2025: Scheme of Selection and Detailed Syllabus
(i) Scheme of Selection
Selection will be through Online/Written Examination (WE) and Interview. There are 3 papers for the examination.
Paper-I: Objective Type (on Statistics) .
Paper-II and Paper-III
The details are as follows:
Name of Paper | Duration | Maximum Marks |
Paper-I: Objective Type (on Statistics) | 120 minutes | 100 |
Paper-II: Descriptive Type (on Statistics) – Question paper displayed on computer, answers to be written on paper | 180 minutes | 100 |
Paper-III: English – Descriptive – To be typed with the help of keyboard | 90 minutes | 100 |
Total | 300 |
Other detailed information regarding the examination will be given in an Information Handout, which will be made available to the candidates for download along with the Admit Card for examination from the RBI website.
Candidates have to secure minimum marks as may be prescribed by the Board.
Candidates who secure the prescribed minimum aggregate marks in Paper-I will be shortlisted for Paper-II and Paper-III of the examination based on the aggregate marks obtained in Paper-I.
The minimum aggregate cut-off marks for being shortlisted for Paper-II and Paper-III of the examination will be decided by the Board in relation to the number of vacancies.
The Roll Numbers of candidates shortlisted for Paper-II and Paper-III examination will be published on the RBI website in due time after the Paper-I examination.
(ii) Paper-II and Paper-III – Online/Written Examination
The Paper-II and Paper-III Examination will be only for candidates who are shortlisted on the basis of the results of Paper-I.
Paper-II and Paper-III examinations will be conducted in shifts. Candidates are required to appear for all the papers in all the shifts.
A single Admit Card will be issued for both shifts.
The timetable for Paper-II and Paper-III will be intimated to the candidates concerned along with the Admit Card for Paper-II and Paper-III.
Medium of Examination
Question papers for the Written Examination (WE) will be set in Hindi and English, except Paper-III on English.
Answers for Paper-II may be written either in Hindi or English.
Paper-III will have to be answered in English only.
Candidates may opt for the Interview in Hindi or English.
(iii) Interview Shortlisting
The number of candidates to be called for the Interview will be decided by the Board.
(iv) Final Selection
Final selection will be on the basis of performance in the Online/Written Examination – Paper-I, Paper-II and Paper-III – and Interview taken together.
The Interview will be of 75 marks.
Candidates may opt for the Interview either in Hindi or English.
(v) Personality Assessment
Candidates will be required to undergo a Personality Assessment conducted by the Bank before appearing for the Interview.
No marks will be allotted for the Personality Assessment, and it will not form part of the final selection criteria.
RBI-DSIM Syllabi
The standard of the papers will be that of a Post-Graduation Degree Examination of any recognized Institution/University in India.
Paper-I and Paper-II
The syllabus for Paper-I and Paper-II consists of the following major areas:
Theory of Probability, Probability Distributions and Sampling Theory
Linear Models and Economic Statistics
Statistical Inference: Estimation, Testing of Hypothesis and Non-Parametric Test
Stochastic Processes
Multivariate Analysis
Econometrics and Time Series
Optimization and Statistical Computing
Data Science, Artificial Intelligence and Machine Learning Techniques
Database and Data Warehouse Management
Detailed Syllabus
1. Theory of Probability, Probability Distributions and Sampling Theory
Probability Theory
Classical and axiomatic approach of probability and its properties.
Bayes Theorem and its application.
Strong and weak laws of large numbers.
Characteristic functions.
Central Limit Theorem.
Probability inequalities.
Probability Distributions
Standard probability distributions:
Binomial
Poisson
Geometric
Negative Binomial
Uniform
Normal
Exponential
Logistic
Log-normal
Beta
Gamma
Weibull
Bivariate Normal, etc.
Sampling Distributions
Exact sampling distributions – Chi-square, Student's t, F and Z distributions and their applications.
Asymptotic sampling distributions and large sample tests.
Association and analysis of contingency tables.
Sampling Theory
Standard sampling methods such as:
Simple Random Sampling
Stratified Random Sampling
Systematic Sampling
Cluster Sampling
Two-stage Sampling
Probability Proportional to Size (PPS), etc.
Ratio Estimation
Regression Estimation
Non-sampling errors
Problem of non-response
2. Linear Models and Economic Statistics
Linear Algebra
Vectors and matrices
Spanning of vector space
Matrix algebra
Inverse of partitioned matrices
g-inverse
Orthogonal matrices
Properties of idempotent matrices
Characteristic roots and vectors
Cayley-Hamilton theorem
Quadratic forms
Definite, semi-definite and indefinite forms
Simultaneous reduction of two quadratic forms
Properties of similar matrices
Regression Analysis
Simple Linear Regression
Assumptions
Estimation
Inference
Diagnostic checks
Other topics include:
Polynomial regression
Transformations on Y or X such as:
Box-Cox transformation
Square-root transformation
Log transformation, etc.
Method of weighted least squares
Inverse regression
Multiple Regression
Standard Gauss-Markov setup
Least squares estimation and related properties
Regression analysis with correlated observations
Simultaneous estimation of linear parametric functions
Testing of hypotheses
Confidence intervals and regions
Multicollinearity
Shrinkage models:
Ridge Regression
LASSO
Elastic Net
Model selection criteria
Residual diagnostics
Categorical data analysis using dummy variables
Outlier detection and treatment
Economic Statistics
Definition and construction of index numbers
Standard index numbers
Conversion of chain-base index to fixed-base and vice versa
Base shifting
Splicing
Deflating of index numbers
Measurement of economic inequality:
Gini's coefficient
Lorenz curves, etc.
Basics of macroeconomics
National accounts
3. Statistical Inference: Estimation, Testing of Hypothesis and Non-Parametric Test
Estimation
Topics include:
Concepts of estimation
Unbiasedness
Sufficiency
Consistency
Efficiency
Factorization theorem
Complete statistic
Minimum Variance Unbiased Estimator (MVUE)
Rao-Blackwell theorem and its applications
Lehmann-Scheffe theorem and its applications
Cramer-Rao inequality
Methods of Estimation
Method of Moments
Maximum Likelihood Estimation
Method of Least Squares
Method of Minimum Chi-square
Basic idea of Bayes estimators
Principles of Test of Significance
Type-I errors
Type-II errors
False-positive errors
False-negative errors
Critical region
Level of significance
Size
p-value and its interpretation
Power
Best critical region
Most powerful test
Uniformly Most Powerful (UMP) test
Neyman-Pearson theory of testing of hypothesis
Likelihood ratio tests
Tests of goodness of fit
Bartlett's test for homogeneity of variances
Non-Parametric Test
The following non-parametric procedures are included:
Kolmogorov-Smirnov test
Sign test
Wilcoxon Signed-Rank test
Wilcoxon Rank-Sum test
Mann-Whitney U-test
Kruskal-Wallis one-way ANOVA test
Friedman's test
Kendall's Tau coefficient
Spearman's coefficient of rank correlation
Other topics include:
Distribution of order statistics
Distribution fitting
Kernel density estimation
4. Stochastic Processes
Poisson Process
Arrival distributions
Interarrival distributions
Conditional arrival distributions
Non-homogeneous processes
Law of Rare Events
Poisson Process
Compound Poisson Processes
Markov Chains
Transition probability matrix
Chapman-Kolmogorov equations
Regular chains
Stationary distributions
Periodicity
Limit theorems
Patterns for recurrent events
Brownian Motion
Limit of Random Walk
Defining characteristics
Peculiarities
Martingales
5. Multivariate Analysis
Topics include:
Multivariate Normal Distribution
Properties and characterization of Multivariate Normal Distribution
Logit-Probit models
Mahalanobis' \(D^2\) statistics
Linear Discriminant Analysis (LDA)
Canonical Correlation Analysis
Principal Components Analysis (PCA)
Factor Analysis
Cluster Analysis
6. Econometrics and Time Series
Econometrics
General linear model and its extensions
Ordinary Least Squares (OLS)
Generalized Least Squares (GLS)
Estimation and prediction
Heteroscedastic disturbances
Pure and mixed estimation
Autocorrelation
Consequences of autocorrelation
Related tests
Theil BLUS procedure
Estimation and prediction
Multicollinearity
Implications of multicollinearity
Tools for handling multicollinearity
Ridge regression
Additional topics:
Linear regression
Stochastic regression
Instrumental Variable Regression
Panel regression
Autoregressive linear regression
Distributed lag models
Estimation of lags by OLS method
Simultaneous linear equations model and its generalization
Identification problem
Restrictions on structural parameters
Rank and order conditions
Different estimation methods for simultaneous equations model
Prediction
Simultaneous confidence intervals
Time Series
Exploratory analysis of time series
Concepts of weak stationarity
Concepts of strong stationarity
AR processes
MA processes
ARMA processes and their properties
Model identification based on ACF and PACF
Model estimation
Diagnostic tests
Box-Jenkins models
ARCH models
GARCH models
Inference with Non-Stationary Models
ARIMA model
SARIMA model
Determination of the order of integration
Trend stationarity
Difference stationarity processes
Tests of non-stationarity
7. Optimization and Statistical Computing
Optimization
Unconstrained optimization using calculus
Taylor's theorem
Convex functions
Coercive functions
Unconstrained optimization through iterative methods:
Newton's method
Gradient-based methods
Conjugate gradient-based methods
Quasi-Newton methods
Constrained optimization
Penalty methods
Lagrange multipliers
Convex sets
Convex hull
Formulation of a Linear Programming Problem
Theorems dealing with vertices of feasible regions and optimality
Graphical solution
Simplex method
Statistical Computing
Simulation techniques for various probability models
Resampling methods:
Jackknife
Bootstrap
Cross-validation
Techniques for robust linear regression
Nonlinear regression
Generalized linear regression problems
Tree-structured regression and classification
Analysis of incomplete data:
EM algorithm
Single imputation
Multiple imputation
Bayesian modelling and estimation
Markov Chain Monte Carlo (MCMC)
Annealing techniques
Gibbs sampling
Metropolis-Hastings algorithm
Neural Networks
Association Rules
Learning algorithms
8. Data Science, Artificial Intelligence and Machine Learning Techniques
Topics include:
Introduction to supervised pattern classification
Introduction to unsupervised pattern classification
Unsupervised learning
Reinforcement learning
Basics of optimization
Model accuracy measures
Linear Regression
Logistic Regression
Penalized Regression
Naïve Bayes
Nearest Neighbor
Decision Tree
Support Vector Machine
Kernel Density Estimation
Kernel Discriminant Analysis
Classification under a regression framework
Neural Networks
Kernel Regression
Trees and Random Forests
Clustering Methods
Hierarchical methods
Non-hierarchical methods
K-means
K-medoids
Linkage methods
Cluster Validation Indices
Dunn Index
Gap Statistics
Ensemble Learning
Bagging
Random Forest
Boosting
Adaptive Boosting
Gradient Boosting
Deep Learning and NLP
Recurrent Neural Network (RNN)
Convolutional Neural Network (CNN)
Natural Language Processing (NLP)
Feature Selection, Regularization and Model Tuning
Recursive Feature Elimination (RFE)
Variance Inflation Factor (VIF)
Ensembling methods
Stacking methods
Elastic Net regularization
Hyperparameter tuning through Grid Search
Feature importance interpretation
Cross-validation strategies
9. Database and Data Warehouse Management
The syllabus includes:
Data structures
Fundamentals of Relational Database Management Systems (RDBMS)
Fundamentals of non-traditional databases
NoSQL databases
Principles of database normalization
Data redundancy elimination
Consistency maintenance
Structured Query Language (SQL)
Querying
Updating
Aggregating
Managing relational data
Database Joins
Inner Join
Left Join
Right Join
Outer Join
Applications of joins to data merging and integration
NoSQL Databases
Overview of:
Document-based databases
Key-value databases
Wide-column stores
Graph databases
Data Warehousing
Data warehousing concepts
Star schemas
Snowflake schemas
ETL – Extract, Transform, Load processes
OLAP vs OLTP
Database indexing
Database optimization
Basics of big-data frameworks
Storage systems for large-scale data handling
Paper-III
English
The paper on English shall be framed in a manner to assess the candidate's writing skills, including expression and understanding of the topic.
C. Manner of Conduct of Examinations for Grade ‘B’ (DR)-DEPR/DSIM
This section deals with the manner in which examinations for RBI Grade ‘B’ (DR)-DEPR/DSIM are conducted.
The standard of papers in General English and General Studies will be such as may be expected of a graduate of an Indian University.
The standard of papers in the other subjects will be that of the Master’s degree examination of an Indian University in the relevant disciplines. The candidates will be expected to illustrate the theory by facts, and to analyze problems with the help of theory. They will be expected to be particularly conversant with Indian problems in the field(s) of Economics/Statistics.
GENERAL ENGLISH
Candidates will be required to write an essay in English. Other questions will be designed to test their understanding of English and workman-like use of words. Passages will usually be set for summary or precis.
GENERAL STUDIES
General knowledge including knowledge of current events and of such matters of everyday observation and experience in their scientific aspects as may be expected of an educated person who has not made a special study of any scientific subject. The paper will also include questions on Indian Polity including the political system and the Constitution of India, History of India, and Geography of nature which a candidate should be able to answer without special study.
STATISTICS-I (OBJECTIVE TYPE)
(i) Probability:
Classical and axiomatic definitions of Probability and consequences. Law of total probability, Conditional probability, Bayes' theorem, and applications. Discrete and continuous random variables. Distribution functions and their properties.
Standard discrete and continuous probability distributions - Bernoulli, Uniform, Binomial, Poisson, Geometric, Rectangular, Exponential, Normal, Cauchy, Hypergeometric, Multinomial, Laplace, Negative binomial, Beta, Gamma, Lognormal. Random vectors, Joint and marginal distributions, conditional distributions, Distributions of functions of random variables. Modes of convergences of sequences of random variables - in distribution, in probability, with probability one and in mean square. Mathematical expectation and conditional expectation. Characteristic function, moment and probability generating functions, Inversion, uniqueness, and continuity theorems. Borel 0-1 law, Kolmogorov's 0-1 law. Tchebycheff's and Kolmogorov's inequalities. Laws of large numbers and central limit theorems for independent variables.
(ii) Statistical Methods:
Collection, compilation, and presentation of data, charts, diagrams, and histogram. Frequency distribution. Measures of location, dispersion, skewness, and kurtosis. Bivariate and multivariate data. Association and contingency. Curve fitting and orthogonal polynomials. Bivariate normal distribution. Regression-linear, polynomial. Distribution of the correlation coefficient, Partial and multiple correlations, Intraclass correlation, Correlation ratio.
Standard errors and large sample tests. Sampling distributions of sample mean, sample variance, t, chi-square, and F; tests of significance based on them, Small sample tests.
Non-parametric tests-Goodness of fit, sign, median, run, Wilcoxon, Mann-Whitney, Wald- Wolfowitz and Kolmogorov-Smirnov. Order statistics-minimum, maximum, range, and median. Concept of Asymptotic relative efficiency.
(iii) Numerical Analysis:
Finite differences of different orders: E and D operators, factorial representation of a polynomial, separation of symbols, sub-division of intervals, differences of zero.
Numerical differentiation: Trapezoidal, Simpson’s one-third, and three-eight rule, and Waddle's rule.
Summation of Series: Whose general term (i) is the first difference of a function (ii) is in geometric progression.
Numerical solutions of differential equations: Euler's Method, Milne’s Method, Picard’s Method, and Runge-Kutta Method.
(iv) Computer application and Data Processing:
Basics of Computer: Operations of a computer, Different units of a computer system like central processing unit, memory unit, arithmetic and logical unit, an input unit, output unit, etc., Hardware including different types of input, output and peripheral devices, Software, system and application software, number systems, Operating systems, packages and utilities, Low and High-level languages, Compiler, Assembler, Memory – RAM, ROM, unit of computer memory (bits, bytes, etc.), Network – LAN, WAN, internet, intranet, basics of computer security, virus, antivirus, firewall, spyware, malware, etc.
Basics of Programming: Algorithm, Flowchart, Data, Information, Database, an overview of different programming languages, frontend and backend of a project, variables, control structures, arrays, and their usages, functions, modules, loops, conditional statements, exceptions, debugging and related concepts.
STATISTICS- II (OBJECTIVE TYPE)
(i) Linear Models:
Theory of linear estimation, Gauss-Markov linear models, estimable functions, error and estimation space, normal equations and least square estimators, estimation of error variance, estimation with correlated observations, properties of least square estimators, the generalized inverse of a matrix, and solution of normal equations, variances, and covariances of least square estimators.
One-way and two-way classifications, fixed, random, and mixed-effects models. Analysis of variance (two-way classification only), multiple comparison tests due to Tukey, Scheffe, and Student-Newmann-Keul-Duncan.
(ii) Statistical Inference and Hypothesis Testing:
Characteristics of a good estimator. Estimation methods of maximum likelihood, minimum chi-square, moments, and least squares. Optimal properties of maximum likelihood estimators. Minimum variance unbiased estimators. Minimum variance bound estimators. Cramer-Rao inequality. Bhattacharya bounds. Sufficient estimator. Factorization theorem. Complete statistics. Rao-Blackwell theorem. Confidence interval estimation. Optimum confidence bounds. Resampling, Bootstrap, and Jackknife.
Hypothesis testing: Simple and composite hypotheses. Two kinds of error. Critical region. Different types of critical regions and similar regions. Power function. Most powerful and uniformly most powerful tests. Neyman-Pearson fundamental lemma. Unbiased test. Randomized test. Likelihood ratio test. Wald's SPRT, OC, and ASN functions. Elements of decision theory.
(iii) Official Statistics:
National and International official statistical system
Official Statistics: (a) Need, Uses, Users, Reliability, Relevance, Limitations, Transparency, its visibility (b) Compilation, Collection, Processing, Analysis and Dissemination, Agencies Involved, Methods
National Statistical Organization: Vision and Mission, NSSO and CSO; roles and responsibilities; Important activities, Publications, etc.
National Statistical Commission: Need, Constitution, its role, functions, etc.; Legal Acts/ Provisions/ Support for Official Statistics; Important Acts
Index Numbers: Different Types, Need, Data Collection Mechanism, Periodicity, Agencies Involved, Uses
Sector Wise Statistics: Agriculture, Health, Education, Women, and Child, etc. Important
Surveys & Census, Indicators, Agencies, and Usages, etc.
National Accounts: Definition, Basic Concepts; issues; the Strategy, Collection of Data and Release.
Population Census: Need, Data Collected, Periodicity, Methods of data collection, dissemination, Agencies involved.
Misc.: Socio-Economic Indicators, Gender Awareness/Statistics, Important Surveys, and Censuses.
STATISTICS- III (DESCRIPTIVE TYPE)
(i) Sampling Techniques:
Concept of population and sample, need for sampling, complete enumeration versus sampling, basic concepts in sampling, sampling and Non-sampling error, Methodologies in sample surveys (questionnaires, sampling design, and methods followed in field investigation) by NSSO.
Subjective or purposive sampling, probability sampling or random sampling, simple random sampling with and without replacement, estimation of population mean, population proportions, and their standard errors. Stratified random sampling, proportional and optimum allocation, comparison with simple random sampling for fixed sample size. Covariance and Variance Function.
ratio, product and regression methods of estimation, estimation of the population mean, evaluation of Bias and Variance to the first order of approximation, comparison with simple random sampling. Systematic sampling (when population size (N) is an integer multiple of sampling size (n)). Estimation of population mean and standard error of this estimate, comparison with simple random sampling. Sampling with probability proportional to size (with and without replacement method), Des Raj and Das estimators for n=2, Horvitz- Thomson’s estimator Equal size cluster sampling: estimators of population mean and total and their standard errors, comparison of cluster sampling with SRS in terms of an intra-class correlation coefficient. Concept of multistage sampling and its application, two-stage sampling with an equal number of second stage units, estimation of population mean and total. Double sampling in ratio and regression methods of estimation. Concept of interpenetrating sub-sampling.
(ii) Econometrics:
Nature of econometrics, the general linear model (GLM) and its extensions, ordinary least squares (OLS) estimation and prediction, generalized least squares (GLS) estimation and prediction, heteroscedastic disturbances, pure and mixed estimation.
Autocorrelation, its consequences, and tests. Theil BLUS procedure, estimation, and prediction, multi-collinearity problem, its implications and tools for handling the problem, ridge regression.
Linear regression and stochastic regression, instrumental variable estimation, errors in variables, autoregressive linear regression, lagged variables, distributed lag models, estimation of lags by OLS method, Koyck’s geometric lag model.
Simultaneous linear equations model and its generalization, identification problem, restrictions on structural parameters, rank and order conditions.
Estimation in simultaneous equations model, recursive systems, 2 SLS estimators, limited information estimators, k-class estimators, 3 SLS estimator, full information maximum likelihood method, prediction, and simultaneous confidence intervals.
(iii) Applied Statistics:
Index Numbers: Price relatives and quantity or volume relatives, Link and chain relatives
composition of index numbers; Laspeyre's, Paasches’, Marshal Edgeworth and Fisher index numbers; chain base index number, tests for index number, Construction of index numbers of wholesale and consumer prices, Income distribution-Pareto, and Engel curves, Concentration curve, Methods of estimating national income, Inter-sectoral flows, Interindustry table, Role of CSO. Demand Analysis
Time Series Analysis: Economic time series, different components, illustration, additive and multiplicative models, determination of trend, seasonal and cyclical fluctuations.
Time-series as discrete parameter stochastic process, autocovariance and autocorrelation functions, and their properties.
Exploratory time Series analysis, tests for trend and seasonality, exponential and moving average smoothing. Holt and Winters smoothing, forecasting based on smoothing.
A detailed study of the stationary processes: (1) moving average (MA), (2) autoregressive (AR), (3) ARMA, and (4) AR integrated MA (ARIMA) models. Box-Jenkins models, choice of AR, and MA periods.
Discussion (without proof) of estimation of mean, autocovariance, and autocorrelation functions under large sample theory, estimation of ARIMA model parameters.
STATISTICS-IV (DESCRIPTIVE TYPE)
(A) Operations Research and Reliability:
Definition and Scope of Operations Research: phases in Operation Research, models and their solutions, decision-making under uncertainty and risk, use of different criteria, sensitivity analysis.
Transportation and assignment problems. Bellman’s principle of optimality, general formulation, computational methods, and application of dynamic programming to LPP.
Decision-making in the face of competition, two-person games, pure and mixed strategies, the existence of solution and uniqueness of value in zero-sum games, finding solutions in 2x2, 2xm, and mxn games.
Analytical structure of inventory problems, EOQ formula of Harris, its sensitivity analysis, and extensions allowing quantity discounts and shortages. Multi-item inventory subject to constraints. Models with random demand, the static risk model. P and Q- systems with constant and random lead times.
Queuing models – specification and effectiveness measures. Steady-state solutions of M/M/1 and M/M/c models with associated distributions of queue-length and waiting time. M/G/1 queue and Pollazcek-Khinchine result.
Sequencing and scheduling problems. 2-machine n-job and 3-machine n-job problems with identical machine sequence for all jobs
Branch and Bound method for solving traveling salesman problem.
Replacement problems – Block and age replacement policies.
PERT and CPM – basic concepts. Probability of project completion.
Reliability concepts and measures, components and systems, coherent systems, reliability of coherent systems. Life-distributions, reliability function, hazard rate, common univariate life distributions – exponential, Weibull, gamma, etc. Bivariate exponential distributions.
Estimation of parameters and tests in these models.
Notions of aging – IFR, IFRA, NBU, DMRL, and NBUE classes and their duals. Loss of memory property of the exponential distribution.
Reliability estimation based on failure times in variously censored life-tests and in tests with the replacement of failed items. Stress-strength reliability and its estimation.
(B) Demography and Vital Statistics:
Sources of demographic data, census, registration, ad-hoc surveys, Hospital records, Demographic profiles of the Indian Census.
Complete life table and its main features, Uses of life table. Markham's and Gompertz's curves. National life tables. UN model life tables. Abridged life tables. Stable and stationary populations.
Measurement of Fertility: Crude birth rate, General fertility rate, Age-specific birth rate, Total fertility rate, Gross reproduction rate, Net reproduction rate.
Measurement of Mortality: Crude death rate, Standardized death rates, Age-specific death rates, Infant Mortality rate, the Death rate by cause.
Internal migration and its measurement, migration models, the concept of international migration.
Net migration. International and postcensal estimates. Projection method including logistic curve fitting. Decennial population census in India.
(C) Survival Analysis and Clinical Trial:
Concept of time, order and random censoring, likelihood in the distributions – exponential, gamma, Weibull, lognormal, Pareto, Linear failure rate, inference for these distributions.
Life tables, failure rate, mean residual life, and their elementary classes and their properties. Estimation of survival function – actuarial estimator, Kaplan – Meier estimator, estimation under the assumption of IFR/DFR, tests of exponentiality against non-parametric classes, total time on the test.
Two sample problems – Gehan test, log-rank test.
Semi-parametric regression for failure rate – Cox’s proportional hazards model with one and several covariates, rank test for the regression coefficient.
Competing risk model, parametric and non-parametric inference for this model.
Introduction to clinical trials: the need and ethics of clinical trials, bias and random error in clinical studies, the conduct of clinical trials, an overview of Phase I – IV trials, multicenter trials.
Data management: data definitions, case report forms, database design, data collection systems for good clinical practice.
Design of clinical trials: parallel vs. cross-over designs, cross-sectional vs. longitudinal designs, review of factorial designs, objectives, and endpoints of clinical trials, design of Phase I trials, design of single-stage and multi-stage Phase II trials, design and monitoring of phase III trials with sequential stopping,
Reporting and analysis: analysis of categorical outcomes from Phase I – III trials, analysis of survival data from clinical trials.
(D) Quality Control:
Statistical process and product control: Quality of a product, need for quality control, the basic concept of process control, process capability, and product control, general theory of control charts, causes of variation in quality, control limits, sub grouping summary of out of control criteria, charts for attributes p chart, np chart, c-chart, V chart, charts for variables: R, (X, R), (X, σ) charts.
Basic concepts of process monitoring and control; process capability and process optimization.
General theory and review of control charts for attribute and variable data; O.C. and A.R.L. of control charts; control by gauging; moving average and exponentially weighted moving average charts; Cu-Sum charts using V-masks and decision intervals; Economic design of X-bar chart.
Acceptance sampling plans for attributes inspection; single and double sampling plans and their properties; plans for inspection by variables for the one-sided and two-sided specification.
(E) Multivariate Analysis:
Multivariate normal distribution and its properties. Random sampling from a multivariate normal distribution. Maximum likelihood estimators of parameters, distribution of the sample mean vector.
Wishart matrix – its distribution and properties, distribution of sample generalized variance, null and non-null distribution of multiple correlation coefficients.
Hotelling’s T2 and its sampling distribution, application in test on mean vector for one and more multivariate normal population and also on equality of components of a mean vector in the multivariate normal population.
Classification problem: Standards of good classification, the procedure of classification based on multivariate normal distributions.
Principal components, dimension reduction, canonical variates, and canonical correlation — definition, use, estimation, and computation.
(F) Design and Analysis of Experiments:
Analysis of variance for one-way and two-way classifications Need for the design of experiments, the basic principle of experimental design (randomization, replication, and local control), complete analysis and layout of the completely randomized design, randomized block design, and Latin square design, Missing plot technique. Split Plot Design and Strip Plot Design.
Factorial experiments and confounding in 2n and 3n experiments. Analysis of covariance. Analysis of non-orthogonal data. Analysis of missing data.
(G) Computing with C and R:
Basics of C: Components of C language, the structure of a C program, Data type, basic data types, Enumerated data types, Derived data types, variable declaration, Local, Global, Parametric variables, Assignment of Variables, Numeric, Character, Real and String constants, Arithmetic, Relation and Logical operators, Assignment operators, Increment and decrement operators, conditional operators, Bitwise operators, Type modifiers and expressions, writing and interpreting expressions, using expressions in statements. Basic input/output.
Control statements: conditional statements, if-else, nesting of if-else, else if ladder, switch statements, loops in c, for, while do-while loops, break, continue, exit ( ), goto, and label declarations, One dimensional two dimensional and multidimensional arrays. Storage classes: Automatic variables, External variables, Static variables, Scope, and a lifetime of declarations.
Functions: classification of functions, functions definition and declaration, assessing a function, return statement, parameter passing in functions. Pointers (concept only).
Structure: Definition and declaration; structure (initialization) comparison of structure variable; Array of structures: array within structures, structures within structures, passing structures to functions; Unions accessing a union member, the union of structure, initialization of a union variable, uses of the union. Introduction to the linked list, linearly linked list, insertion of a node in the list, removal of a node from the list.
Files in C: Defining and opening a file, input-output operation on a file, creating a file, reading a file. Statistics Methods and techniques in R.




